MECHANISM OF ACTION

MECHANISM OF ACTION

Reblozyl addresses ineffective late-stage erythropoiesis by promoting erythroid maturation^1-3

Reblozyl is a recombinant fusion protein that binds selected TGF-β superfamily ligands to reduce Smad 2/3 signaling, which is abnormally high in disease models characterized by ineffective erythropoiesis, (ie, MDS and β-thalassemia), and in the bone marrow of patients with MDS.^1-3

Reblozyl is the first and only erythroid maturation agent¹

Reblozyl is the first and only erythroid maturation agent¹

Reblozyl is a recombinant fusion protein that binds selected TGF-β superfamily ligands to reduce Smad 2/3 signaling, which is abnormally high in disease models characterized by ineffective erythropoiesis, (ie, MDS and β-thalassemia), and in the bone marrow of patients with MDS.^1-3

References:

1. Reblozyl^® (luspatercept) Summary of Product Characteristics (SmPC). Celgene 2020.

2. Suragani RN, Cadena SM, Cawley SM, et al. Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis. Nat Med. 2014;20(4):408-414.

3. Attie KM, Allison MJ, McClure T, et al. A phase 1 study of ACE-536, a regulator of erythroid differentiation, in healthy volunteers. Am J Hematol. 2014;89(7):766-770.

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▼This medicinal product is subject to additional monitoring. This will allow quick identification of new safety information. Healthcare professionals are asked to report any suspected adverse reactions. See Section 4.8 in the EU Summary of Product Characteristics for more information. Before prescribing Reblozyl, please refer to the
EU Summary of Product Characteristics.